Trifluoroacetic Acid

Trifluoroacetic acid (Cas: 76-05-1) is used as a medicine, pesticide intermediate, biochemical reagent, and organic synthesis reagent. It is an important organic synthesis reagent, from which various fluorine-containing compounds, pesticides and dyes can be synthesized. Trifluoroacetic acid is also a catalyst for esterification and condensation reactions; it can also serve as a protective agent for hydroxyl and amino groups and is used in the synthesis of sugars and polypeptides.

When used with carbon disulfide, it dissolves protein. It is also an excellent solvent for organic reactions. Results that are difficult to obtain in general organic solvents can be obtained. For example, when quinoline is catalytically hydrogenated in a general solvent, the pyridine ring is hydrogenated preferentially, but the benzene ring is hydrogenated preferentially in tri-Chemicalbook fluoroacetic acid. Trifluoroacetic acid is used to synthesize fluorinated compounds, pesticides and dyes. It is a catalyst for esterification and condensation reactions; a protective agent for hydroxyl and amino groups, used in the synthesis of sugars and polypeptides. It is also used as a mineral dressing agent.

It is mainly used in the production of new pesticides, medicines and dyes, and also has great application development potential in materials, solvents and other fields. Trifluoroacetic acid is mainly used to synthesize a variety of herbicides containing trifluoromethyl and heterocyclic rings. Currently, a variety of new herbicides with pyridyl and quinolinyl groups can be synthesized; as a very strong protic acid, it is widely used in aromatic compounds. Catalyst for alkylation, acylation, olefin polymerization and other reactions; As a solvent, trifluoroacetic acid is an excellent solvent for fluorination, nitration and halogenation reactions. In particular, its derivative trifluoroacetyl group has excellent chemical protection on hydroxyl groups and amino groups. It has very important applications in the synthesis of amino acids and polypeptide compounds. It is used to remove the t-butoxycarbonyl (t-boc) protecting group of amino acids in polypeptide synthesis; As a raw material and modifier for preparing ionic membranes, trifluoroacetic acid can greatly improve the current efficiency of the caustic soda industry and extend the service life of the membrane; trifluoroacetic acid can also synthesize trifluoroethanol, trifluoroacetaldehyde andtrifluoroacetic anhydride。Mercury trifluoroacetate causes fluorobenzene to undergo mercurization (electrophilic substitution) at room temperature, and can also convert hydrazones into diazo compounds. The lead salt of this acid converts aromatic hydrocarbons into phenols.

In experiments for separating polypeptides and proteins by reverse phase chromatography, the use of trifluoroacetic acid (TFA) as an ion pair reagent is a common means. Trifluoroacetic acid in the mobile phase improves peak shape and overcomes Chemicalbook peak broadening and tailing problems by interacting in multiple modes with the hydrophobically bonded phase and residual polar surfaces. The reason why trifluoroacetic acid is superior to other ionic modifiers is that it is easy to volatilize and can be easily removed from prepared samples. On the other hand, the ultraviolet absorption maximum peak of trifluoroacetic acid is below 200nm, which has little interference with the detection of polypeptides at low wavelengths.

Application in HPLC
In experiments for separating polypeptides and proteins by reverse phase chromatography, the use of trifluoroacetic acid (TFA) as an ion pair reagent is a common means. Trifluoroacetic acid in the mobile phase improves peak shape and overcomes peak broadening and tailing problems by interacting in multiple modes with the hydrophobically bonded phase and residual polar surfaces. Trifluoroacetic acid combines with positive charges and polar groups on the Chemicalbook polypeptide to reduce polarity retention and bring the polypeptide back to the hydrophobic reverse surface. In the same way, trifluoroacetic acid shields the remaining polar surfaces on the stationary phase. The behavior of trifluoroacetic acid can be understood as that it stays on the surface of the reversed phase stationary phase and interacts with the polypeptide and the column bed.

physical indexes
Molecular weight 114.02
UN Code 2699
Dangerous goods class 8
Melting point ℃ -15
Boiling point ℃ 72.4
Flash point ℃ >100
Density g/cm3 1.535
Refractive index,n20/D 1.3

quality Index
Purity ≥99.5%
Moisture ≤0.1%
pH 1
Appearance, odor Colorless transparent liquid, pungent smell

packaging methods
25kg/plastic drum
200kg/plastic-lined iron barrel